Rab GTPases drive ligand‐independent NOTCH1 activation via altered endocytic trafficking in chronic lymphocytic leukemia
Filomena De Falco, Beatrice Del Papa, Daniele Sorcini, Letizia Valmarini, Francesco Maria Adamo, Andrea Atzeni, Angela Esposito, Estevão Carlos Silva Barcelos, Erica Dorillo, Arianna Stella, Roberta Arcaleni, Fabio Gurrieri, Miriam Pugliese, Gabriele Astolfi, Maria Paola Martelli, Mauro Di Ianni, Emanuela Rosati, Paolo Sportoletti · 2026
Read Rab GTPases drive ligand‐independent NOTCH1 activation via altered endocytic trafficking in chronic lymphocytic leukemia by Filomena De Falco, Beatrice Del Papa, Daniele Sorcini, Letizia Valmarini, Francesco Maria Adamo, Andrea Atzeni, Angela Esposito, Estevão Carlos Silva Barcelos, Erica Dorillo, Arianna Stella, Roberta Arcaleni, Fabio Gurrieri, Miriam Pugliese, Gabriele Astolfi, Maria Paola Martelli, Mauro Di Ianni, Emanuela Rosati, Paolo Sportoletti (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13410950.txt.
Description
Filomena De Falco and colleagues reveal in 2026 how leukemia cells switch on a growth signal without waiting for its usual trigger. The signal, NOTCH1, often fires in chronic lymphocytic leukemia even when its gene is normal. The team suspected the cell's internal shipping routes do the work instead.
Tags on the protein showed it gathering with two shipping station markers, Rab5 and Rab7, inside small cell compartments. Blocking entry into those compartments stopped the active signal piece from forming. The cutting enzyme that frees it also sat in the same stations. Silencing the Rab proteins lowered the signal and pushed leukemia cells toward death, which nominates the shipping route as a drug target.
Catalog record
| CREATOR | Filomena De Falco, Beatrice Del Papa, Daniele Sorcini, Letizia Valmarini, Francesco Maria Adamo, Andrea Atzeni, Angela Esposito, Estevão Carlos Silva Barcelos, Erica Dorillo, Arianna Stella, Roberta Arcaleni, Fabio Gurrieri, Miriam Pugliese, Gabriele Astolfi, Maria Paola Martelli, Mauro Di Ianni, Emanuela Rosati, Paolo Sportoletti |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |