NF-κB/OCT−1 Mediated Upregulation of CXCL14 Chemokine Mobilizes Mucosal Effector Memory CD44+CD62L-CD4+ and CD8+ TEM Cells, and NK Cells Associated with Protection Against Genital Herpes
Yassir Lekbach, Swayam Prakash, Hawa Vahed, Afshana Quadiri, Azizur Rahman, El Houcine El Fatimi, Joshua Christian Dorotta, Baverly Sabathini Suoth, Chhaya Maurya, America Garcia, Gina Park, Lbachir BenMohamed · 2026
Read NF-κB/OCT−1 Mediated Upregulation of CXCL14 Chemokine Mobilizes Mucosal Effector Memory CD44+CD62L-CD4+ and CD8+ TEM Cells, and NK Cells Associated with Protection Against Genital Herpes by Yassir Lekbach, Swayam Prakash, Hawa Vahed, Afshana Quadiri, Azizur Rahman, El Houcine El Fatimi, Joshua Christian Dorotta, Baverly Sabathini Suoth, Chhaya Maurya, America Garcia, Gina Park, Lbachir BenMohamed (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13410923.txt.
Description
Yassir Lekbach and colleagues traced in 2026 how a signal protein, CXCL14, rallies immune defenders against genital herpes. The paper compares immune cells from women with and without symptoms, tests human vaginal lining cells, and follows mice lacking the signal after vaginal infection with herpes simplex virus type 2.
Mice without CXCL14 suffered worse sores, higher virus levels, and lower survival, while their recruitment of killer cells and memory T cells fell short. The paper points to CXCL14 as a possible lever for vaccines or treatments that strengthen local defense where herpes first takes hold.
Catalog record
| CREATOR | Yassir Lekbach, Swayam Prakash, Hawa Vahed, Afshana Quadiri, Azizur Rahman, El Houcine El Fatimi, Joshua Christian Dorotta, Baverly Sabathini Suoth, Chhaya Maurya, America Garcia, Gina Park, Lbachir BenMohamed |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |