Hypothalamic Control of Liver Health and Disease: From Circuits to Pathophysiology and Therapies
Qin Tang, Jiahui Li, Haiying Song, Ailin Zhang, Haifeng Zeng, Yining Xu, Li Mo, Jinhan He · 2026
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Description
Qin Tang and colleagues review in 2026 how the hypothalamus, a small brain region, directs liver health from afar. The liver runs the body's fuel supply, yet it takes orders from more than local nutrients and hormones. Brain circuits sense body state and tune liver sugar, fat, bile, and repair work.
When that brain-liver axis misfires, diseases follow, from fatty liver to liver cancer. The review maps the nerve and hormone routes involved and how their flexibility turns harmful under strain. New therapies aim at the interface itself, from circuit-specific drugs to electronic nerve modulation. Turning those ideas into clinic-ready tools remains the hard part, the authors note.
Catalog record
| CREATOR | Qin Tang, Jiahui Li, Haiying Song, Ailin Zhang, Haifeng Zeng, Yining Xu, Li Mo, Jinhan He |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 81 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |