TRP120-dependent activation of noncanonical Wnt/NFAT signaling drives monocyte chemokine production in Ehrlichia chaffeensis infection
Regina N. Solomon, Duc-Cuong Bui, Ayana P. Pai, Jere W. McBride · 2026
Read TRP120-dependent activation of noncanonical Wnt/NFAT signaling drives monocyte chemokine production in Ehrlichia chaffeensis infection by Regina N. Solomon, Duc-Cuong Bui, Ayana P. Pai, Jere W. McBride (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13410762.txt.
Description
Regina Solomon and colleagues show in 2026 how a tick-borne bacterium tricks white blood cells into calling in more targets. Ehrlichia chaffeensis lives inside those cells and hijacks several of their signal systems to dodge immune attack. One hijacked route, a nonstandard Wnt pathway, switches on a factor called NFAT.
In infected lab cells, only one NFAT form, NFATc1, switched on, and cells poured out chemicals that attract more monocytes. A bacterial protein named TRP120 copied much of that effect on its own. Blocking NFAT or removing the Wnt receiver on cells cut both the signal and the chemical output. Both outside signals and inside action of the protein proved necessary for the full effect.
Catalog record
| CREATOR | Regina N. Solomon, Duc-Cuong Bui, Ayana P. Pai, Jere W. McBride |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55238 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |