Causal relationships between the gut microbiota, immune cells, and diabetic kidney disease: a Mendelian randomization and mediation analysis
Han Yan, Haipeng Pang, Lingxiang Xie, Jin Ding, Yiman Peng, Yuanqin Yang, Zhiguang Zhou, Xi Li, Jingyi Hu · 2026
Read Causal relationships between the gut microbiota, immune cells, and diabetic kidney disease: a Mendelian randomization and mediation analysis by Han Yan, Haipeng Pang, Lingxiang Xie, Jin Ding, Yiman Peng, Yuanqin Yang, Zhiguang Zhou, Xi Li, Jingyi Hu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13410746.txt.
Description
Han Yan and a large team probe in 2026 whether gut microbes help cause kidney damage in diabetes, using genes as natural experiments. Watch-and-see studies had linked the two, yet cause could run either way. The method used compares people whose genes nudge microbe levels up or down across a lifetime.
Data came from genome studies of gut microbes, kidney disease, and immune cell traits. Five microbe groups and seven immune traits showed causal ties to diabetic kidney disease after strict corrections. Immune cells carried part of the effect for some microbes: one species raised risk partly by lowering a marker on regulatory T cells. The chain from gut to immune system to kidney is the paper's main message.
Catalog record
| CREATOR | Han Yan, Haipeng Pang, Lingxiang Xie, Jin Ding, Yiman Peng, Yuanqin Yang, Zhiguang Zhou, Xi Li, Jingyi Hu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |