A Dual‐Bioresponsive and Programmable Microneedle Matrix as a Bioinspired Coupler for Orchestrating Diabetic Bone Regeneration
Yu Wang, Rui Chen, Yu Chen, Haowen Lu, Yuchen Qian, Zhiheng Gao, Zheming Shen, Xiaofei Zheng, Huilin Yang, Jun Zou, Yusen Qiao · 2026
Read A Dual‐Bioresponsive and Programmable Microneedle Matrix as a Bioinspired Coupler for Orchestrating Diabetic Bone Regeneration by Yu Wang, Rui Chen, Yu Chen, Haowen Lu, Yuchen Qian, Zhiheng Gao, Zheming Shen, Xiaofei Zheng, Huilin Yang, Jun Zou, Yusen Qiao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13410640.txt.
Description
Yu Wang and a large team present in 2026 a dissolving microneedle patch meant to heal bone defects in diabetes. Bone repair in diabetes stalls amid infection risk and lasting inflammation. Their patch reacts to two signals of that hostile setting before releasing its cargo in sequence.
Surface peptides stay locked until bacterial enzymes free the germ-killing one to attack biofilms first. Rising glutathione, a marker of the inflamed site, then frees a calming peptide that nudges immune cells toward repair mode. Growth factors held in the patch core leak out last to build vessels and bone. In diabetic mice with bone defects, healing improved and new bone grew more strongly than without the timed release.
Catalog record
| CREATOR | Yu Wang, Rui Chen, Yu Chen, Haowen Lu, Yuchen Qian, Zhiheng Gao, Zheming Shen, Xiaofei Zheng, Huilin Yang, Jun Zou, Yusen Qiao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 122323 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |