Janus Polymeric Nanorods Inhibit human Amylin Oligomerization and Fibrillation for Potential Type 2 Diabetes Treatment
Mathilde Jégo, Sandra Kalem, Irene Antignano, David Siefker, Mingsheng Ji, Julia Kaffy, Lynda Benrabah, Chloé Cayrou, Kawthar Bouchemal, Mélanie Hery, Erwan Nicol, Sandrine Pensec, Jutta Rieger, Claire Smadja, Sandrine Ongeri, Laurent Bouteiller, Olivier Colombani, Myriam Taverna · 2026
Read Janus Polymeric Nanorods Inhibit human Amylin Oligomerization and Fibrillation for Potential Type 2 Diabetes Treatment by Mathilde Jégo, Sandra Kalem, Irene Antignano, David Siefker, Mingsheng Ji, Julia Kaffy, Lynda Benrabah, Chloé Cayrou, Kawthar Bouchemal, Mélanie Hery, Erwan Nicol, Sandrine Pensec, Jutta Rieger, Claire Smadja, Sandrine Ongeri, Laurent Bouteiller, Olivier Colombani, Myriam Taverna (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13410570.txt.
Description
Mathilde Jégo leads a large team reporting in 2026 on two-faced polymer nanorods that slow the clumping of a diabetes-linked protein. In type 2 diabetes, human amylin folds wrongly and piles into fibers that harm the insulin-making cells of the pancreas. Many past blockers lacked precision or worked weakly.
The rods carry a small binding ligand on one face only, letting them grip amylin from several points at once. Lab assays showed the fitted rods kept amylin in its single form, delayed fiber start, and worked at doses below the amount of amylin present. Plain rods and free ligand did far less. The rods spared an unrelated clumping protein and cut amylin harm in cell models.
Catalog record
| CREATOR | Mathilde Jégo, Sandra Kalem, Irene Antignano, David Siefker, Mingsheng Ji, Julia Kaffy, Lynda Benrabah, Chloé Cayrou, Kawthar Bouchemal, Mélanie Hery, Erwan Nicol, Sandrine Pensec, Jutta Rieger, Claire Smadja, Sandrine Ongeri, Laurent Bouteiller, Olivier Colombani, Myriam Taverna |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 85 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |