A novel approach to improving solubility of drugs: chelation-assisted solubility enhancement (CHASE)
TanPhat Nguyen, Nicola Bauer, Samer Gozem, Binghe Wang · 2026
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Description
TanPhat Nguyen and colleagues test in 2026 a trick to make hard-to-dissolve drugs dissolve better by grabbing metal ions. Many drug candidates fail because they shun water. Their idea, called CHASE, hangs a ring that traps sodium or potassium onto a water-shy compound.
Six compounds were built and their liking for oily versus watery layers was measured with and without metal salts. One ring-bearing compound shifted strongly toward water once sodium was present. Forces between the metal and aromatic rings also shaped the results. The authors argue that lab tests of drug behavior should routinely include the metal ions found in body fluids, since those ions can change outcomes a lot.
Catalog record
| CREATOR | TanPhat Nguyen, Nicola Bauer, Samer Gozem, Binghe Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |