Self‐Assembling Cationic Lipopeptides for the Construction of Functional Vesicular Gene‐Delivery Systems
Federica A. Souto‐Trinei, Alba Ramil‐Bouzas, Paco Fernández‐Trillo, Ana Rey‐Rico, Roberto J. Brea · 2026
Read Self‐Assembling Cationic Lipopeptides for the Construction of Functional Vesicular Gene‐Delivery Systems by Federica A. Souto‐Trinei, Alba Ramil‐Bouzas, Paco Fernández‐Trillo, Ana Rey‐Rico, Roberto J. Brea (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13410438.txt.
Description
Souto-Trinei and co-authors create, in 2026, cationic lipopeptides, molecules fusing fat-loving lipid tails with plus-charged peptides, that assemble themselves into hollow vesicles able to ferry genes into cells without viruses. Viral carriers work well but are immunogenic and hard to make; these synthetic compartments mimic cell membranes while staying body-friendly and programmable.
The assemblies grabbed nucleic acids eagerly. The best performer, LP2, reached about 90 percent complexation at 20 micrograms per milliliter and stayed efficient across a broad range, while LP1 managed roughly 85 percent binding in assays. Transfection of the easy HEK 293T cell line was strong, and performance extended to mesenchymal stem cells, a harder target. Cells survived at above 75 percent at all tested concentrations, beating the 62 percent survival of the positive control in their comparisons. The authors envision programmable cells delivering varied nucleic acids into hard-to-transfect cells.
Catalog record
| CREATOR | Federica A. Souto‐Trinei, Alba Ramil‐Bouzas, Paco Fernández‐Trillo, Ana Rey‐Rico, Roberto J. Brea |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |