Diagnostic Test Accuracy of Detecting Donor‐Derived Cell‐Free DNA in Renal Transplant Rejection: A Systematic Review and Meta‐Analysis
Chee Siong Wong, Yegor Tryliskyy, Raja Rashid, Sowrav Barman, Vlad Shuymeko, Ajay Sharma, Mohammed Hossain, Giuseppe Tisone · 2026
Read Diagnostic Test Accuracy of Detecting Donor‐Derived Cell‐Free DNA in Renal Transplant Rejection: A Systematic Review and Meta‐Analysis by Chee Siong Wong, Yegor Tryliskyy, Raja Rashid, Sowrav Barman, Vlad Shuymeko, Ajay Sharma, Mohammed Hossain, Giuseppe Tisone (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13410283.txt.
Description
Chee Siong Wong and colleagues gather in 2026 the evidence on a blood test that spots kidney transplant rejection without a biopsy. The test measures DNA fragments shed by the donor organ into the recipient's blood. When rejection starts, those fragments rise, so levels may warn doctors early.
Searching four databases under standard review rules, the team found 13 studies covering 2,214 samples. Pooled results gave modest sensitivity of about 61 percent and stronger specificity near 83 percent for rejection overall. For rejection driven by antibodies, sensitivity rose to about 76 percent with similar specificity. Too little data existed for cell-driven rejection, so that side of the test stays unsettled.
Catalog record
| CREATOR | Chee Siong Wong, Yegor Tryliskyy, Raja Rashid, Sowrav Barman, Vlad Shuymeko, Ajay Sharma, Mohammed Hossain, Giuseppe Tisone |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |