Beta2-adrenergic receptor activation increases susceptibility to arrhythmogenesis in aging heart by impairing repolarization reserve via Giβγ–PLC signaling pathway
Sihao Zou, Yi Wang, Jia Chen, Li Yan, Lijie Gao, Kexin Li, Xianying Wang, Congxin Li · 2026
Read Beta2-adrenergic receptor activation increases susceptibility to arrhythmogenesis in aging heart by impairing repolarization reserve via Giβγ–PLC signaling pathway by Sihao Zou, Yi Wang, Jia Chen, Li Yan, Lijie Gao, Kexin Li, Xianying Wang, Congxin Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13408997.txt.
Description
Sihao Zou and co-authors study why stimulating a certain adrenaline receptor makes aging hearts prone to dangerous rhythms in a 2026 paper. Experiments used guinea pig hearts, both whole and in dishes, plus human heart cells grown from stem cells. In aging hearts, the corrected QT interval and the electrical recovery time were longer. Aged heart cells also adjusted far less when the beat sped up.
A drug that activates the receptor shortened recovery in young hearts but not in old ones, which instead became prone to fast abnormal rhythms. In lab aged human cells, the drug delayed recovery and triggered arrhythmias. Blocking steps in one signaling chain reduced the arrhythmias, and a drug that boosts a protective potassium current also helped. The authors map a route from receptor to rhythm risk in the aging heart.
Catalog record
| CREATOR | Sihao Zou, Yi Wang, Jia Chen, Li Yan, Lijie Gao, Kexin Li, Xianying Wang, Congxin Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |