Long-term spatiotemporal evolution of drug-resistant Mycobacterium tuberculosis in China
Yiwang Chen, Jialei Liang, Dongxin Liu, Peng Xu, Qi Jiang, Tingting Yang, Qingyun Liu, Howard E. Takiff, Sebastien Gagneux, Qian Gao · 2026
Read Long-term spatiotemporal evolution of drug-resistant Mycobacterium tuberculosis in China by Yiwang Chen, Jialei Liang, Dongxin Liu, Peng Xu, Qi Jiang, Tingting Yang, Qingyun Liu, Howard E. Takiff, Sebastien Gagneux, Qian Gao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13408820.txt.
Description
Yiwang Chen and team rebuilt the long-term evolution of drug-resistant tuberculosis across China from over 18,000 bacterial genomes. Their 2026 work takes on a gap: antibiotics have treated tuberculosis for over 80 years, yet population-level dynamics of resistance under drug pressure had been poorly mapped. Spatial and temporal patterns matter for control plans.
Resistance mutations to varied drugs arose time and again, forming hundreds to over a thousand small resistant clades, mostly arising in the past two decades. Once set, clades spread mainly within provinces, but could widen with human movement and bacterial fitness. Genomic and CRISPRi data flagged mutations tied to resistance rise and spread. The work highlights migration and bacterial adaptation as shapers of local drug-resistant tuberculosis epidemics.
Catalog record
| CREATOR | Yiwang Chen, Jialei Liang, Dongxin Liu, Peng Xu, Qi Jiang, Tingting Yang, Qingyun Liu, Howard E. Takiff, Sebastien Gagneux, Qian Gao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |