Spatiotemporal organisation of residual disease in mouse and human BRCA1-deficient mammary tumours and breast cancer
Demeter Túrós, Morgane Decollogny, Anna Moyseos, Astrid Chanfon, Myriam Siffert, Joanne Bousmar, Lou Romanens, Jean-Christophe Tille, Olivier Tredan, Intidhar Labidi-Galy, Alberto Valdeolivas, Sven Rottenberg · 2026
Read Spatiotemporal organisation of residual disease in mouse and human BRCA1-deficient mammary tumours and breast cancer by Demeter Túrós, Morgane Decollogny, Anna Moyseos, Astrid Chanfon, Myriam Siffert, Joanne Bousmar, Lou Romanens, Jean-Christophe Tille, Olivier Tredan, Intidhar Labidi-Galy, Alberto Valdeolivas, Sven Rottenberg (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13408813.txt.
Description
Demeter Túrós and colleagues chart in 2026 where the cancer cells that survive chemotherapy hide in BRCA1-deficient breast tumours, and what they look like. Such leftover cells, called minimal residual disease, seed relapse, yet their organisation in space and time was unmapped. Mouse mammary tumours lacking BRCA1 and p53, plus human samples, were followed across treatment using single-cell sequencing, spatial gene mapping, and imaging of many proteins at once.
A distinct population of drug-tolerant cells running an epithelial-to-mesenchymal transition programme emerged as the survivors. The same programme appears in human BRCA1-deficient tumours and tracks with worse patient outcomes. These cells clustered in particular anatomical niches rather than scattering randomly, and drugs could target them in preclinical models. The map gives researchers concrete places and programmes to attack before relapse begins.
Catalog record
| CREATOR | Demeter Túrós, Morgane Decollogny, Anna Moyseos, Astrid Chanfon, Myriam Siffert, Joanne Bousmar, Lou Romanens, Jean-Christophe Tille, Olivier Tredan, Intidhar Labidi-Galy, Alberto Valdeolivas, Sven Rottenberg |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 125611 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |