Spatial architecture of autism pathogenesis reveals mosaic structural disarray during early development
Li Lin, Tzuen Yih Saw, Nigel Chou, Jie Lin Jolene Goh, Jing Eugene Kwa, Wan Kee Chock, Vipul Singhal, Zheng Li, Mike J. Huang, Huck Hui Ng, Chiea Chuen Khor, Hwee Lee Kuan, Kok Hao Chen, Shyam Prabhakar, Jinyue Liu · 2026
Read Spatial architecture of autism pathogenesis reveals mosaic structural disarray during early development by Li Lin, Tzuen Yih Saw, Nigel Chou, Jie Lin Jolene Goh, Jing Eugene Kwa, Wan Kee Chock, Vipul Singhal, Zheng Li, Mike J. Huang, Huck Hui Ng, Chiea Chuen Khor, Hwee Lee Kuan, Kok Hao Chen, Shyam Prabhakar, Jinyue Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13408761.txt.
Description
Li Lin and a large team map in 2026 how autism-related disorganisation is laid out in space inside developing brain tissue. Autism has hundreds of genetic contributors and wide clinical variety, yet how its biology first takes shape was unclear. The team grew prenatal cortex organoids from genetically diverse patients and read gene activity cell by cell and place by place.
Healthy zoning between progenitor and neuron regions broke down, leaving local patches of disorganised neurons whose placement differed from patient to patient. The disorder persisted as neurons matured and pointed to weakened adhesion between progenitor cells. Because each patient's mosaic pattern is different, the authors propose that scattered spatial abnormalities arising before birth could explain why symptoms and brain structure vary so much across the spectrum.
Catalog record
| CREATOR | Li Lin, Tzuen Yih Saw, Nigel Chou, Jie Lin Jolene Goh, Jing Eugene Kwa, Wan Kee Chock, Vipul Singhal, Zheng Li, Mike J. Huang, Huck Hui Ng, Chiea Chuen Khor, Hwee Lee Kuan, Kok Hao Chen, Shyam Prabhakar, Jinyue Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 86437 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |