DNA methylation reprogramming in marsupial embryos is restricted to the extraembryonic lineage
Allegra Angeloni, Jillian M. Hammond, Timothy J. Peters, Andre L. M. Reis, Leah Kemp, Timothy G. Amos, Hasindu Gamaarachchi, Sam Humphries, Lynda A. Wilmott, Suranjana Pal, V. Pragathi Masamsetti, Megan Weatherstone, Chi Kin Ip, Karina Pazaky, Alice Steel, Ruth Lyons, Elly D. Walters, Ning Liu, Patrick Tam, Jose M. Polo, Paul D. Waters, Susan J. Clark, Linda J. Richards, Andrew D. Smith, Heather J. Lee, Ira W. Deveson, Oliver W. Griffith, Ksenia Skvortsova · 2026
Read DNA methylation reprogramming in marsupial embryos is restricted to the extraembryonic lineage by Allegra Angeloni, Jillian M. Hammond, Timothy J. Peters, Andre L. M. Reis, Leah Kemp, Timothy G. Amos, Hasindu Gamaarachchi, Sam Humphries, Lynda A. Wilmott, Suranjana Pal, V. Pragathi Masamsetti, Megan Weatherstone, Chi Kin Ip, Karina Pazaky, Alice Steel, Ruth Lyons, Elly D. Walters, Ning Liu, Patrick Tam, Jose M. Polo, Paul D. Waters, Susan J. Clark, Linda J. Richards, Andrew D. Smith, Heather J. Lee, Ira W. Deveson, Oliver W. Griffith, Ksenia Skvortsova (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13408496.txt.
Description
Allegra Angeloni and a large Australian team ask in 2026 whether the wide erasure of DNA methylation in early embryos evolved with the placenta. Mouse and human embryos wipe this chemical mark almost everywhere, then rebuild it. The tissue that becomes the placenta stays bare. Marsupials, which grow a short-lived placenta, offer the test case.
Working with the fat-tailed dunnart, the team produced a near-complete genome and tracked methylation through development. The dunnart embryo did erase methylation at the blastocyst stage. Yet it did so only in the trophectoderm, the placenta-forming lineage. The embryo proper stayed untouched. That pattern suggests placental erasure is the older state for mammals. It predates the long pregnancy of placental mammals. For epigenetics readers, the timeline of a basic process in early life shifts by a wide margin.
Catalog record
| CREATOR | Allegra Angeloni, Jillian M. Hammond, Timothy J. Peters, Andre L. M. Reis, Leah Kemp, Timothy G. Amos, Hasindu Gamaarachchi, Sam Humphries, Lynda A. Wilmott, Suranjana Pal, V. Pragathi Masamsetti, Megan Weatherstone, Chi Kin Ip, Karina Pazaky, Alice Steel, Ruth Lyons, Elly D. Walters, Ning Liu, Patrick Tam, Jose M. Polo, Paul D. Waters, Susan J. Clark, Linda J. Richards, Andrew D. Smith, Heather J. Lee, Ira W. Deveson, Oliver W. Griffith, Ksenia Skvortsova |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70569 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |