Tumor-resident T cells and dendritic cells form an in situ archetype during immunotherapy response in melanoma
Andrea Di Pietro, Lewis Au, Patrick Crock, Niko Thio, Angela Pizzolla, Thu Ngoc Nguyen, Sean Macdonald, Hugh Chalmers, Ruiqing Zhu, Alessia Airaghi, Tristan Molden-Hauer, Marina Bacac, Petra Schwalie, Ramona Schlenker, Mitchell P Levesque, Sonia Mailer, Kristy Barnes-Cullen, Karen Winch, Joanna Chan, George Au Yeung, Lavinia Spain, Aparna D Rao, Shahneen Sandhu, David E Gyorki, Grant A McArthur, Laura K Mackay, Paul J Neeson · 2026
Read Tumor-resident T cells and dendritic cells form an in situ archetype during immunotherapy response in melanoma by Andrea Di Pietro, Lewis Au, Patrick Crock, Niko Thio, Angela Pizzolla, Thu Ngoc Nguyen, Sean Macdonald, Hugh Chalmers, Ruiqing Zhu, Alessia Airaghi, Tristan Molden-Hauer, Marina Bacac, Petra Schwalie, Ramona Schlenker, Mitchell P Levesque, Sonia Mailer, Kristy Barnes-Cullen, Karen Winch, Joanna Chan, George Au Yeung, Lavinia Spain, Aparna D Rao, Shahneen Sandhu, David E Gyorki, Grant A McArthur, Laura K Mackay, Paul J Neeson (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13408351.txt.
Description
Andrea Di Pietro and a large Australian team profiled melanoma lymph node samples in 2026 to learn what responding tumours contain that resistant ones lack. T cells that take up residence inside tumours are known guardians against melanoma, yet their part in checkpoint immunotherapy success had not been mapped in full.
Thirty-two samples from untreated, responding, and resistant patients were profiled cell by cell and in place. Responding tumours were rich in resident CD8 and CD4 T cells that had multiplied and switched on killing programmes, while resistant tumours showed exhausted cells stuck in chronic interferon signalling. Only responders held an organised trio of the two resident T-cell types plus a particular dendritic cell. That spatial pattern could become a biomarker for predicting who benefits from treatment.
Catalog record
| CREATOR | Andrea Di Pietro, Lewis Au, Patrick Crock, Niko Thio, Angela Pizzolla, Thu Ngoc Nguyen, Sean Macdonald, Hugh Chalmers, Ruiqing Zhu, Alessia Airaghi, Tristan Molden-Hauer, Marina Bacac, Petra Schwalie, Ramona Schlenker, Mitchell P Levesque, Sonia Mailer, Kristy Barnes-Cullen, Karen Winch, Joanna Chan, George Au Yeung, Lavinia Spain, Aparna D Rao, Shahneen Sandhu, David E Gyorki, Grant A McArthur, Laura K Mackay, Paul J Neeson |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 90551 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |