Phenolic compound-mediated covalent crosslinking as a universal mechanism for cellulase deactivation during lignocellulose saccharification
Ya-Jun Liu, Chao Chen, Shenglei Wu, Guang-Lei Liu, Yingang Feng · 2026
Read Phenolic compound-mediated covalent crosslinking as a universal mechanism for cellulase deactivation during lignocellulose saccharification by Ya-Jun Liu, Chao Chen, Shenglei Wu, Guang-Lei Liu, Yingang Feng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13408160.txt.
Description
Ya-Jun Liu and co-authors investigate in 2026 why plant material resists being turned into sugars. Factories use cellulase enzymes to break down tough plant fibres, yet compounds in the biomass quietly switch those enzymes off. The study identifies phenolic compounds, especially phenolic aldehydes, as the culprits behind much of that loss.
Experiments showed the phenolics form permanent chemical bonds with enzyme side chains, a process that needs oxygen and links enzyme molecules together until they stop working. Removing oxygen, or adding competing amino compounds, reduced the damage. The phenolics came both from lignin breakdown and from raw plant extractives. For biofuel and biorefining readers, the work gives practical pretreatment guidance: limit leftover phenolics so enzymes keep working longer.
Catalog record
| CREATOR | Ya-Jun Liu, Chao Chen, Shenglei Wu, Guang-Lei Liu, Yingang Feng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59869 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |