HnRNP A1 and A2B1 enforce Ezh2 mRNA splicing to promote germinal center B cell responses
Zhijian Zhu, Rui Zhang, Haoran Kang, Meiyuan Chen, Hengjun Huang, Jing Wang, Ling Guo, Yuxing Li, Wenjing Chen, Limin Meng, Ruisi Wang, Ling Li, Kong-Peng Lam, Shengli Xu, Xijun Ou · 2026
Read HnRNP A1 and A2B1 enforce Ezh2 mRNA splicing to promote germinal center B cell responses by Zhijian Zhu, Rui Zhang, Haoran Kang, Meiyuan Chen, Hengjun Huang, Jing Wang, Ling Guo, Yuxing Li, Wenjing Chen, Limin Meng, Ruisi Wang, Ling Li, Kong-Peng Lam, Shengli Xu, Xijun Ou (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13408116.txt.
Description
Zhijian Zhu and co-authors trace, in 2026, how two near-identical RNA-binding proteins keep antibody factories running. Germinal centres are where B cells multiply and refine antibodies during immune responses. Deleting the genes for hnRNP A1 and A2B1 in mouse B cells crippled that reaction. Proliferation fell, and high-affinity antibody output dropped.
The mechanism is splicing control: the proteins grip UAG-rich motifs in the Ezh2 gene's raw transcript and force inclusion of exon 14, keeping the EZH2 enzyme catalytically active. Without them, exon skipping yields a dead enzyme, a cell-cycle brake protein accumulates, and B cells stall. Deleting that brake partly rescued the defect. An axis linking splicing to epigenetic control of immunity is the authors' formulation.
Catalog record
| CREATOR | Zhijian Zhu, Rui Zhang, Haoran Kang, Meiyuan Chen, Hengjun Huang, Jing Wang, Ling Guo, Yuxing Li, Wenjing Chen, Limin Meng, Ruisi Wang, Ling Li, Kong-Peng Lam, Shengli Xu, Xijun Ou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 84753 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |