Molecular evidence for early deuterostome origins of ovarian cell types and neuroendocrine control of reproduction
Periklis Paganos, Beverly Naigles, Carsten Wolff, Danila Voronov, S Zachary Swartz · 2026
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Description
Periklis Paganos and co-authors use, in 2026, a sea star to ask how the ovary's cell types evolved. Egg production needs germline cells and supporting body cells working together. The sea star Patiria miniata is a non-chordate relative of ours. It produces millions of eggs across its life. That makes it a practical window on ancient arrangements.
Single-cell RNA sequencing combined with sharp 3D imaging catalogued the sea star ovary's cell types and their layout. The team found candidate egg stem cells plus supporting cells resembling mammalian granulosa and theca cells, along with plausible signalling conversations between support and germline cells. Most intriguingly, the ovary may run its own hormone-like control system, suggesting hormone-like control of reproduction predates the vertebrates.
Catalog record
| CREATOR | Periklis Paganos, Beverly Naigles, Carsten Wolff, Danila Voronov, S Zachary Swartz |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 87928 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |