Diagnostic challenges and Gram-negative pathogen dominance in early- and late-onset neonatal infection in Manila, Philippines
Michelle L Harrison, Maria E Villanueva-Uy, Erena Kasahara, Julie Jaynney Caparas, Nover Edward Duarte, Alkim Ozaygen, Patrick Cahill, Jill Hopkins, Tamalee Roberts, Yue Wu, Tom Snelling, H Rogier van Doorn, Paul Turner, Phoebe C M Williams · 2026
Read Diagnostic challenges and Gram-negative pathogen dominance in early- and late-onset neonatal infection in Manila, Philippines by Michelle L Harrison, Maria E Villanueva-Uy, Erena Kasahara, Julie Jaynney Caparas, Nover Edward Duarte, Alkim Ozaygen, Patrick Cahill, Jill Hopkins, Tamalee Roberts, Yue Wu, Tom Snelling, H Rogier van Doorn, Paul Turner, Phoebe C M Williams (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13407861.txt.
Description
Michelle L. Harrison and a large team report, in 2026, a year of surveillance for suspected infection in newborns at Manila's Philippine General Hospital. Most knowledge about newborn sepsis comes from wealthy countries. The team enrolled every intensive-care baby with a suspected infection. Enrolment ran from November 2023 to November 2024. The tally was 799 babies and 1,024 episodes.
The diagnostic gap was stark. Only 1 percent of suspected early infections, appearing in the first two days of life, grew anything from blood culture. Fifteen percent of the babies died, including 53 percent of those with lab-confirmed infection and 12 percent of those without. Gram-negative bacteria dominated confirmed cases per the study's framing. The authors urge better case definitions and testing capacity, partly to curb antibiotic overuse driven by uncertainty.
Catalog record
| CREATOR | Michelle L Harrison, Maria E Villanueva-Uy, Erena Kasahara, Julie Jaynney Caparas, Nover Edward Duarte, Alkim Ozaygen, Patrick Cahill, Jill Hopkins, Tamalee Roberts, Yue Wu, Tom Snelling, H Rogier van Doorn, Paul Turner, Phoebe C M Williams |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45766 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |