Plasma Glial Fibrillary Acidic Protein (GFAP) shows age-dependent associations with externalizing psychopathology and atypical brain connectivity
B S Niveditha, Bharath Holla, Sarada Subramanian, N Gagana, K M Bhargavi, Eesha Sharma, Jayant Mahadevan, Meera Purushottam, Biju Viswanath, Vivek Benegal, Gautham Arunachal, Jon Heron, Matthew Hickman, Debasish Basu, B N Subodh, Lenin Singh, Roshan Singh, Kalyanaraman Kumaran, Rebecca Kuriyan, Suni · 2026
Read Plasma Glial Fibrillary Acidic Protein (GFAP) shows age-dependent associations with externalizing psychopathology and atypical brain connectivity by B S Niveditha, Bharath Holla, Sarada Subramanian, N Gagana, K M Bhargavi, Eesha Sharma, Jayant Mahadevan, Meera Purushottam, Biju Viswanath, Vivek Benegal, Gautham Arunachal, Jon Heron, Matthew Hickman, Debasish Basu, B N Subodh, Lenin Singh, Roshan Singh, Kalyanaraman Kumaran, Rebecca Kuriyan, Suni (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13407853.txt.
Description
B S Niveditha and team tied a blood marker of glial activation to acting-out behavior and brain connectivity in young people. Their 2026 cross-sectional work draws 144 people from the Indian cVEDA group, matched into acting-out and healthy control groups, gauging plasma GFAP and neurofilament light chain alongside resting-state brain imaging. Acting-out disorders, marked by impulsivity and aggression, lack clear biological fingerprints.
A clear age-by-group interaction showed for GFAP, with acting-out youth showing higher levels only under age 14, while neurofilament showed no clear effect. A five-feature connectivity fingerprint tracked with GFAP, featuring stronger sensorimotor-limbic and attention-default links and weaker within-default-mode links. The work proposes an age-bound glial fingerprint for early acting-out pathology, pending long-term proof.
Catalog record
| CREATOR | B S Niveditha, Bharath Holla, Sarada Subramanian, N Gagana, K M Bhargavi, Eesha Sharma, Jayant Mahadevan, Meera Purushottam, Biju Viswanath, Vivek Benegal, Gautham Arunachal, Jon Heron, Matthew Hickman, Debasish Basu, B N Subodh, Lenin Singh, Roshan Singh, Kalyanaraman Kumaran, Rebecca Kuriyan, Suni |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |