Mutational Landscape of FGFR4 Across Malignancies: A Cross-Cancer Analysis of the AACR Project GENIE Database
Henna Ali, Tyler Gengnagel, Salem Birkholz, Gowri Vadmal, Elijah Torbenson, Beau Hsia, Abubakar Tauseef, Peter T. Silberstein · 2026
Read Mutational Landscape of FGFR4 Across Malignancies: A Cross-Cancer Analysis of the AACR Project GENIE Database by Henna Ali, Tyler Gengnagel, Salem Birkholz, Gowri Vadmal, Elijah Torbenson, Beau Hsia, Abubakar Tauseef, Peter T. Silberstein (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13407695.txt.
Description
Henna Ali and co-authors survey, in 2026, mutations in the FGFR4 gene across human cancers using a large shared genomic database. FGFR4 helps drive cell growth and blood-vessel formation. Yet it is far less studied than its three sibling receptors. The team catalogued its mutations in the AACR Project GENIE collection.
The analysis covered 4,565 tumour samples from 4,283 patients. Mutations appeared most often in lung cancer, colorectal cancer, and melanoma, clustering in the protein's kinase and immunoglobulin-like domains with similar patterns across cancer types. One hotspot group, at amino acid 401, carried a higher mutation burden. More companion alterations appeared too. Closer checks blamed a subset of hypermutated tumours, not the hotspot itself. Sex showed no link, while ancestry groups differed.
Catalog record
| CREATOR | Henna Ali, Tyler Gengnagel, Salem Birkholz, Gowri Vadmal, Elijah Torbenson, Beau Hsia, Abubakar Tauseef, Peter T. Silberstein |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42443 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |