Proteostasis Dysfunction and Heat Shock Protein Networks in Intervertebral Disc Degeneration: Molecular Mechanisms and Therapeutic Opportunities
Zhaoxi Wang, Shijie Chen, Zhaoheng Wang, Yong Sun, Kun Wang, Xuewen Kang · 2026
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Description
Zhaoxi Wang and co-authors survey, in 2026, heat shock proteins and protein housekeeping in worn spinal discs, a leading source of low back pain. Heat shock proteins act as chaperones that refold stressed proteins, and in disc tissue they can protect cells or, in other settings, feed the damage process.
The review tracks members such as HSP70, HSP90, and HSP27 across the disc. They appear in its gel-like centre and its fibrous outer ring. The authors tie them to inflammation, cell death, and matrix turnover. Tuning these chaperones could pair with biomaterials, physical stimulation, or regenerative approaches. Direct disc-specific evidence for some family members is still scarce, a gap the authors flag for future work.
Catalog record
| CREATOR | Zhaoxi Wang, Shijie Chen, Zhaoheng Wang, Yong Sun, Kun Wang, Xuewen Kang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66572 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |