Targeting ABCB6 induces ferroptosis in osteosarcoma cells via HIF1A/GPX4 pathway
梓立 林, 浩 罗, 湘尧 李, 伟 罗 · 2026
Read Targeting ABCB6 induces ferroptosis in osteosarcoma cells via HIF1A/GPX4 pathway by 梓立 林, 浩 罗, 湘尧 李, 伟 罗 (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13407292.txt.
Description
Lin and co-authors report a 2026 study of a gene called ABCB6 in osteosarcoma, a bone cancer seen most in teens. This cancer spreads early and often resists drugs, so survival has barely improved. The gene helps move iron and build haem in cells. Its role in this bone cancer had not been explored before.
The team mapped where the gene is active, what it means for patient outlook, and what it does in tumor cells. Work used two human bone cancer cell lines and stem cells from bone marrow. Blocking the gene drove a form of iron-linked cell death. The path ran through two named partner genes.
Catalog record
| CREATOR | 梓立 林, 浩 罗, 湘尧 李, 伟 罗 |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |