Prevention of Gastrointestinal Bleeding in Patients Receiving Direct Oral Anticoagulants: A Narrative Review and Practical Framework for Prescribers
Nicoleta Dubei, Larisa Anghel, Laura-Cătălina Benchea, Radu Andy Sascău, Cristina Prisacariu, Mircea Ovanez Balasanian, Bogdan-Sorin Tudurachi, Bianca-Ștefania Profire, Cristian Stătescu · 2026
Read Prevention of Gastrointestinal Bleeding in Patients Receiving Direct Oral Anticoagulants: A Narrative Review and Practical Framework for Prescribers by Nicoleta Dubei, Larisa Anghel, Laura-Cătălina Benchea, Radu Andy Sascău, Cristina Prisacariu, Mircea Ovanez Balasanian, Bogdan-Sorin Tudurachi, Bianca-Ștefania Profire, Cristian Stătescu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13407246.txt.
Description
Nicoleta Dubei and co-authors offer prescribers, in 2026, a practical plan for preventing gut bleeding in patients taking direct oral anticoagulants, the blood thinners now widely used for atrial fibrillation. These drugs beat older thinners on convenience, yet bleeding in the stomach or bowel remains their most common serious side effect outside the skull.
Drawing on trials, real-world studies, and guidelines from 2004 to 2025, the review ties risk to existing gut disease, other illnesses, and companion drugs such as anti-inflammatory painkillers. Among the thinners, apixaban repeatedly showed the kindest gut profile, while rivaroxaban and high-dose dabigatran bled more. Suggested defences include treating Helicobacter infection, acid-suppressing medicine for high-risk patients, dropping needless companion drugs, and matching drug choice to the individual.
Catalog record
| CREATOR | Nicoleta Dubei, Larisa Anghel, Laura-Cătălina Benchea, Radu Andy Sascău, Cristina Prisacariu, Mircea Ovanez Balasanian, Bogdan-Sorin Tudurachi, Bianca-Ștefania Profire, Cristian Stătescu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54804 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |