Evaluation of Human Sperm Quality In Vitro—Purification of Motile Sperm and Subsequent Assessment of Potential Apoptotic Signs Beyond DNA Fragmentation
Satoru Kaneko, Yukako Kuroda, Yuki Okada · 2026
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Description
Satoru Kaneko, Yukako Kuroda, and Yuki Okada review, in 2026, how to judge human sperm quality beyond the usual count and movement checks, with an eye on sperm injection treatment for infertility. Earlier work from the group used density gradients to separate lively sperm without DNA damage from still sperm carrying fragmented DNA.
New dye- and lectin-based tests probe the sperm's outer and acrosomal membranes, internal oxidative stress, and internal cavities, sorting cells that look pre-decline from those already breaking down. For injection, the authors describe the ideal candidate: oval head, intact membranes, healthy energy production, and no DNA damage or vacuoles. Setting firm thresholds is hard because several faults often coexist in one cell, a problem the review maps out.
Catalog record
| CREATOR | Satoru Kaneko, Yukako Kuroda, Yuki Okada |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35513 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |