MYD88/TRIF Signaling, Pluripotency and Klotho Regulation in the Intestine, Kidneys, Liver, and Lungs of a Septic Mouse Model
Maria Erodotou, Alkistis Kapelouzou, Konstantinos S. Mylonas, Ioanna Soukouli, John N. Boletis, Gerasimos Tsourouflis, Theodore Liakakos, Dimitrios Schizas · 2026
Read MYD88/TRIF Signaling, Pluripotency and Klotho Regulation in the Intestine, Kidneys, Liver, and Lungs of a Septic Mouse Model by Maria Erodotou, Alkistis Kapelouzou, Konstantinos S. Mylonas, Ioanna Soukouli, John N. Boletis, Gerasimos Tsourouflis, Theodore Liakakos, Dimitrios Schizas (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13407125.txt.
Description
Maria Erodotou and co-authors tracked, in 2026, how immune signalling unfolds across organs during sepsis in mice. Sepsis, the body's damaging overreaction to infection, can fail several organs at once, and two relay routes inside immune cells, named MYD88 and TRIF, sit near its centre.
The team measured gene activity in gut, kidney, liver, and lung tissue at 24, 48, and 72 hours after inducing sepsis surgically. Immune messengers, infection-fighting interferons, and hypoxia-linked genes all rose versus controls, growing stronger over time and differing by organ. Genes tied to cell identity and a longevity-related protein called Klotho were part of the panel. The time- and tissue-specific pattern, the authors suggest, could guide treatments matched to the stage of illness.
Catalog record
| CREATOR | Maria Erodotou, Alkistis Kapelouzou, Konstantinos S. Mylonas, Ioanna Soukouli, John N. Boletis, Gerasimos Tsourouflis, Theodore Liakakos, Dimitrios Schizas |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34116 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |