Epigenetic Patterns in Musculoskeletal Disease: Methylation of DKK1, RHOJ, and SOX6 Genes in Osteoarthritis and Osteoporosis
Anton V. Tyurin, Bulat I. Yalaev, Karina E. Akhiiarova, Ilmira I. Galina, Jie Li, Rita I. Khusainova · 2026
Read Epigenetic Patterns in Musculoskeletal Disease: Methylation of DKK1, RHOJ, and SOX6 Genes in Osteoarthritis and Osteoporosis by Anton V. Tyurin, Bulat I. Yalaev, Karina E. Akhiiarova, Ilmira I. Galina, Jie Li, Rita I. Khusainova (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13407114.txt.
Description
Anton V. Tyurin and co-authors, in 2026, compared chemical tagging on three bone-related genes in postmenopausal women with joint wear, bone thinning, both together, or neither. Osteoarthritis and osteoporosis often travel together, yet shared molecular roots remain murky, so the team read tagging at single sites in blood DNA from 96 women.
Women with both conditions showed heavier tagging at two DKK1 sites. The comparison group had joint disease alone. One DKK1 site was lighter in that joint-only group than in controls. A model mixing three DKK1 sites with one in SOX6 separated the combined-condition group with modest accuracy. The pattern hints at a shared signature behind the paired diseases, worth testing in larger groups.
Catalog record
| CREATOR | Anton V. Tyurin, Bulat I. Yalaev, Karina E. Akhiiarova, Ilmira I. Galina, Jie Li, Rita I. Khusainova |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47764 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |