Berberine Attenuates Cadmium-Induced Nephrotoxicity by Suppressing LDHA-Mediated Glycolytic Reprogramming and Restoring Mitochondrial TCA Cycle Metabolism
Zikang Zeng, Weidong Qiao, Yuanyuan Zhang, Shusheng Tang · 2026
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Description
Zikang Zeng and co-authors, in 2026, tested whether berberine, a plant compound, can shield mouse kidneys from cadmium poisoning. Cadmium builds up in kidneys and disrupts energy handling and oxidation balance, yet berberine's protective reach there had not been mapped well.
Male mice received cadmium daily for 30 days, with or without berberine at two doses. Cadmium raised injury markers, damaged kidney tissue, and weakened antioxidant defences, while berberine softened each change in line with dose. Chemical profiling showed cadmium suppressing energy-cycle intermediates and berberine restoring many of them. The compound also lowered a key glycolysis enzyme in tissue tests, and computer modelling suggested it binds that enzyme stably.
Catalog record
| CREATOR | Zikang Zeng, Weidong Qiao, Yuanyuan Zhang, Shusheng Tang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33973 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |