Gut-bone metabolites: SCFAs, polyamines and microbial metabolomics in osteoporosis risk and therapy (Review)
Fuchao Chen, Jingyue Sun, Xiao Wang · 2026
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Description
Fuchao Chen, Jingyue Sun and Xiao Wang review gut microbe products as bone protectors in a 2026 survey. Osteoporosis thins bone and raises fracture risk, and research now links it to the gut through chemical messengers. Two families of messengers take centre stage: short-chain fatty acids and polyamines.
Fatty acids from fibre fermentation slow bone-eating cells and help bone-building cells through named receptor and gene pathways. Polyamines such as spermidine likewise favour bone formation and restrain breakdown. Genetic and multi-omics studies add causal hints tying specific gut microbes to bone risk. The review also covers measurement platforms and a translation mechanism, eIF5A hypusination, as fresh angles for therapy.
Catalog record
| CREATOR | Fuchao Chen, Jingyue Sun, Xiao Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 90305 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |