Cyclodextrin inclusion complexes enhance the solubility and anti-virulence activity of metronidazole against uropathogenic Proteus mirabilis
Rehab Mahmoud Abd El-Baky, Zeinab Fathalla, Hala Rady Ahmed, Ramadan Yahia, Mohamed A. Mawhoup, Ghada M. Sadiq, Hebatallah S. Barakat, Adel Al Fatease, Ali H. Alamri, Hamdy Abdelkader, Reham Mokhtar ELTarabili, Reham Mokhtar ELTarabili, Reham Mokhtar ELTarabili · 2026
Read Cyclodextrin inclusion complexes enhance the solubility and anti-virulence activity of metronidazole against uropathogenic Proteus mirabilis by Rehab Mahmoud Abd El-Baky, Zeinab Fathalla, Hala Rady Ahmed, Ramadan Yahia, Mohamed A. Mawhoup, Ghada M. Sadiq, Hebatallah S. Barakat, Adel Al Fatease, Ali H. Alamri, Hamdy Abdelkader, Reham Mokhtar ELTarabili, Reham Mokhtar ELTarabili, Reham Mokhtar ELTarabili (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13405122.txt.
Description
Rehab Mahmoud Abd El-Baky and co-authors package the antibiotic metronidazole inside sugar rings to fight a urinary bacterium, in 2026 work. Proteus mirabilis causes catheter-linked urine infections and infection stones, and often resists drugs. Improving an old drug's solubility is one route around resistance.
Three cyclodextrin hosts were mixed or kneaded with the drug, and the products were checked with heat and infrared methods. Two hosts improved how fast the drug dissolved, and one cut the amount needed to stop bacterial growth four-fold in the reported tests. At lower doses the packages also curbed bacterial swimming, urease activity and biofilm growth. The approach targets virulence as well as growth.
Catalog record
| CREATOR | Rehab Mahmoud Abd El-Baky, Zeinab Fathalla, Hala Rady Ahmed, Ramadan Yahia, Mohamed A. Mawhoup, Ghada M. Sadiq, Hebatallah S. Barakat, Adel Al Fatease, Ali H. Alamri, Hamdy Abdelkader, Reham Mokhtar ELTarabili, Reham Mokhtar ELTarabili, Reham Mokhtar ELTarabili |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 88 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |