Exploring the mechanism of Shuangyu Granule in regulating immune-inflammatory responses in influenza through UPLC-Orbitrap-MS/MS, GC-MS, and network target analysis
Ling Sun, ZhiTao Jiang, Ying Chen, MingShu Han, YaoZhong Lv, Liang Li, XinZhuang Zhang, Liang Cao, TuanJie Wang, ZhenZhong Wang, Wei Xiao · 2026
Read Exploring the mechanism of Shuangyu Granule in regulating immune-inflammatory responses in influenza through UPLC-Orbitrap-MS/MS, GC-MS, and network target analysis by Ling Sun, ZhiTao Jiang, Ying Chen, MingShu Han, YaoZhong Lv, Liang Li, XinZhuang Zhang, Liang Cao, TuanJie Wang, ZhenZhong Wang, Wei Xiao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13405112.txt.
Description
Ling Sun and co-authors dissect a Chinese herbal granule used for flu, in 2026 laboratory work. Shuangyu Granule is a traditional formula said to calm the immune inflammation that influenza triggers. Its active ingredients and pathways were largely unmapped.
Two mass spectrometry methods profiled the granule, finding 148 components in the product and 21 that entered the blood in prototype form. Network analysis, joined with single-cell data from flu patients, predicted which immune genes those components might hit. Computer docking suggested the compounds could bind those targets. In macrophage inflammation models, the absorbed components showed the predicted calming effects in the reported validation tests.
Catalog record
| CREATOR | Ling Sun, ZhiTao Jiang, Ying Chen, MingShu Han, YaoZhong Lv, Liang Li, XinZhuang Zhang, Liang Cao, TuanJie Wang, ZhenZhong Wang, Wei Xiao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |