Longitudinal plasma p-tau217 as a marker for tracking progression and predicting cognitive decline in Alzheimer’s disease
Jehyun Ahn, Jihwan Yun, Michael W. Weiner, Daeun Shin, Heekyoung Kang, Sohyun Yim, Seonghyeon Kim, Heekyoung Park, Hyemin Jang, Min Young Chun, Eun Hye Lee, Hee Jin Kim, Duk L. Na, Jun Pyo Kim, Sang Won Seo, the ADNI study group · 2026
Read Longitudinal plasma p-tau217 as a marker for tracking progression and predicting cognitive decline in Alzheimer’s disease by Jehyun Ahn, Jihwan Yun, Michael W. Weiner, Daeun Shin, Heekyoung Kang, Sohyun Yim, Seonghyeon Kim, Heekyoung Park, Hyemin Jang, Min Young Chun, Eun Hye Lee, Hee Jin Kim, Duk L. Na, Jun Pyo Kim, Sang Won Seo, the ADNI study group (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13404311.txt.
Description
Jehyun Ahn and co-authors follow a blood marker of Alzheimer's disease over time to see if it can track and foretell decline. The marker, plasma p-tau217, matches brain amyloid and tau pathology well in single snapshots. Its behavior across stages and test platforms was less charted. Their 2026 study analyzes 393 participants from a North American Alzheimer's cohort, both unimpaired and impaired. Five assay platforms measure the same blood. Mixed models trace each person's trajectory.
The marker rises significantly over time on every platform, in both groups. The steepest standardized climb marks one platform-group pairing in the data. Annual changes are then set against a standard dementia rating scale. The design tests prognosis by amyloid status, the clinically live question. Blood tracking, if it holds, could spare scans and spinal taps.
Catalog record
| CREATOR | Jehyun Ahn, Jihwan Yun, Michael W. Weiner, Daeun Shin, Heekyoung Kang, Sohyun Yim, Seonghyeon Kim, Heekyoung Park, Hyemin Jang, Min Young Chun, Eun Hye Lee, Hee Jin Kim, Duk L. Na, Jun Pyo Kim, Sang Won Seo, the ADNI study group |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |