Integrated analysis of human-mouse gut microbiota in RSV infection based on machine learning
You Duan, Chen Guo, Liang Xie, Hanmin Liu, Yang Liu · 2026
Read Integrated analysis of human-mouse gut microbiota in RSV infection based on machine learning by You Duan, Chen Guo, Liang Xie, Hanmin Liu, Yang Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13403644.txt.
Description
You Duan and team joined gut microbe data from children and mice with respiratory syncytial virus infection using machine learning. Their 2026 work pools five public datasets with 319 samples, hunting shared gut-lung signals for probiotic therapy work. RSV causes severe lower lung infection in children, yet care options stay thin and prior microbe studies were small and scattered.
Infection upset child gut microbe structure, lowering variety, while mice showed higher variety and different leading germs. Thirteen machine-learning models predicted disease best in child data, hitting an AUC of 0.952, and cross-species study found 62 family-level and 54 genus-level taxa shared as key traits. Function profiles reshaped during infection. The work offers candidate probiotic targets, while cross-species gaps temper direct transfer.
Catalog record
| CREATOR | You Duan, Chen Guo, Liang Xie, Hanmin Liu, Yang Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |