Convection-Enhanced Delivery of Tumor-Infiltrating Lymphocytes Enhances Intratumoral Distribution and Therapeutic Efficacy in an Orthotopic Rat Glioma Model
Yuan Zhou, Liwen Zhu, Xinglei Liu, Chunxia Ji, Jiakai Yao, Di Chen, Yu Yao · 2026
Read Convection-Enhanced Delivery of Tumor-Infiltrating Lymphocytes Enhances Intratumoral Distribution and Therapeutic Efficacy in an Orthotopic Rat Glioma Model by Yuan Zhou, Liwen Zhu, Xinglei Liu, Chunxia Ji, Jiakai Yao, Di Chen, Yu Yao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13403505.txt.
Description
Yuan Zhou and colleagues tested in 2026 a pressure-driven way to deliver tumor-fighting immune cells into rat brain tumors. Cells taken from a tumor can attack it, yet getting enough of them deep into brain tissue is hard. A slow pressure infusion can push fluid past the blood-brain barrier.
Rats given the pressure method had immune cells spread wider through the tumor than rats given a plain needle dose. Tumors grew more slowly, cell-death signals rose, and treated rats lived longer. Healthy rats showed no clear harm in the short check window. The team calls the result an early proof of concept for local brain therapy.
Catalog record
| CREATOR | Yuan Zhou, Liwen Zhu, Xinglei Liu, Chunxia Ji, Jiakai Yao, Di Chen, Yu Yao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47864 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |