Autophagy Modulation in Cancer Therapy: Navigating the Dual Roles to Overcome Chemoresistance
Md Mohiuddin, Md Al Mamun Ahsan · 2026
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Description
Md Mohiuddin and Md Al Mamun Ahsan write a perspective on autophagy, the cell recycling system, as a double-edged target in cancer therapy. Early in cancer, recycling suppresses tumors. In established tumors it keeps stressed cells alive and blunts chemotherapy. That feeds the resistance that defeats treatment. The balance shifts with tumor stage, which cell groups are present, and the surroundings, which is why simple on-off strategies disappoint.
First-generation blockers such as hydroxychloroquine and chloroquine sensitize some tumors in the lab and have reached trials, but they lack specificity and bring off-target toxicity. The authors spotlight narrower pathways, mitophagy and ER-phagy among them. They argue for precision approaches: selective blockers, markers that warn ahead, and nanoparticle delivery that controls where and when autophagy is touched. Their verdict is promise with discipline.
Catalog record
| CREATOR | Md Mohiuddin, Md Al Mamun Ahsan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |