Pediatric Clostridiodes difficile infection with toxic megacolon successfully treated with fecal microbiota transplantation
Dana McCarney, Pamela Chen, Jenna Simes, Stacy A. Kahn · 2026
Read Pediatric Clostridiodes difficile infection with toxic megacolon successfully treated with fecal microbiota transplantation by Dana McCarney, Pamela Chen, Jenna Simes, Stacy A. Kahn (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13403027.txt.
Description
Dana McCarney and colleagues report the first child with fulminant Clostridioides difficile infection and toxic megacolon cured by fecal microbiota transplant. Child cases are rising, above all in medically fragile children, and transplant of healthy donor stool bacteria is established for repeating infections but untested in this fulminant, colon-swelling form. Their patient was critically ill when the transplant was tried.
Standard drugs had failed, and surgery looked dangerous because the child had neutropenia and prior abdominal radiation for rhabdomyosarcoma, a muscle cancer. After the transplant, symptoms resolved rapidly and no adverse events followed. The authors argue stool transplant belongs on the option list for severe pediatric infection when drugs fail and the operating room is a poor bet. One success, they note, cannot set dosing or timing.
Catalog record
| CREATOR | Dana McCarney, Pamela Chen, Jenna Simes, Stacy A. Kahn |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 8 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |