Clozapine for Post-traumatic Stress Disorder: Redefining Treatment Resistance in Soldiers without Psychosis
Roshan Monaragala, Miyuru Chandradasa, KALA Kuruppuarachchi · 2026
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Description
Roshan Monaragala, Miyuru Chandradasa, and KALA Kuruppuarachchi report seven soldiers whose post-traumatic stress disorder had resisted standard care and who improved on clozapine, a drug normally reserved for psychosis. None of the seven had psychosis. Standard trauma therapy and first-line antidepressants leave many patients stuck: full remission reaches only about 20 to 30 percent of treated cases in the figures the authors cite.
At clozapine doses from 125 to 300 milligrams, the soldiers functioned better and showed less aggression. No validated treatment path exists for resistant PTSD without psychosis, and no earlier study had tested clozapine for that group, according to the authors. They frame their series as a reason to study the drug properly rather than proof it works. Seven cases, no control group, and a medicine with heavy monitoring needs all demand caution before wider use.
Catalog record
| CREATOR | Roshan Monaragala, Miyuru Chandradasa, KALA Kuruppuarachchi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 15 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |