The CEBPB–AP-1 (JunB/Fos) Axis Drives Neuroinflammation and Microglial Dysfunction Via TNF Signaling in Ischemic Stroke
Kun Liang, Shuangshuang Lu, Weihao Shi, Weijian Fan, Yijun Huang, Jianwei Chen, Lei Zhu · 2026
Read The CEBPB–AP-1 (JunB/Fos) Axis Drives Neuroinflammation and Microglial Dysfunction Via TNF Signaling in Ischemic Stroke by Kun Liang, Shuangshuang Lu, Weihao Shi, Weijian Fan, Yijun Huang, Jianwei Chen, Lei Zhu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13402266.txt.
Description
Kun Liang and colleagues identified a gene-control axis that drives brain inflammation after ischemic stroke in mice. Their 2026 study focuses on microglia, brain immune cells that can both worsen damage and aid repair after a blocked brain vessel. The molecular switches that set microglia toward harm or healing had remained inadequately defined.
Gene profiling of microglia after transient focal ischemia highlighted CEBPB, JunB, Fos, and TNF as hub genes. CEBPB switched on the AP-1 complex by binding the Fos promoter, raising inflammatory mediators including interleukin-1 beta and TNF-alpha. Blocking AP-1 with T-5224 shifted microglia toward repair, reduced neuron death, and improved long-term movement and thinking in mice. The axis is a promising drug target, pending human translation.
Catalog record
| CREATOR | Kun Liang, Shuangshuang Lu, Weihao Shi, Weijian Fan, Yijun Huang, Jianwei Chen, Lei Zhu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |