Monitoring the Effect of Tributyltin Salicylate and Propionate, Retinoid X Receptor Ligands, on Heat Shock Protein Expression in MDA‐MB‐231 Cells by MALDI MS/MS
Dana Strouhalova, Dana Macejova, Julius Brtko, Janette Bobalova · 2026
Read Monitoring the Effect of Tributyltin Salicylate and Propionate, Retinoid X Receptor Ligands, on Heat Shock Protein Expression in MDA‐MB‐231 Cells by MALDI MS/MS by Dana Strouhalova, Dana Macejova, Julius Brtko, Janette Bobalova (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13401854.txt.
Description
Dana Strouhalova and co-authors examine how two tin-based compounds change heat shock protein levels in breast cancer cells. Organotin compounds can trigger programmed cell death through mitochondria and may also bind the retinoid X receptor, a hormone-sensing protein. Their 2026 study treats the human breast cancer cell line known as MDA-MB-231 with tributyltin propionate and tributyltin salicylate.
Protein patterns were separated by gel electrophoresis and identified with MALDI mass spectrometry, with special attention to heat shock proteins. These protective proteins are often overproduced in cancer cells and help tumours progress and resist therapy. Both tin compounds significantly reduced heat shock protein expression in the treated cells. The authors suggest heat shock proteins could be a promising target through which such compounds exert anticancer effects, building on the compounds' known ability to drive apoptosis.
Catalog record
| CREATOR | Dana Strouhalova, Dana Macejova, Julius Brtko, Janette Bobalova |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |