Real-world clinical outcomes and economic burden of discontinuation of taxane therapy among patients with metastatic castration-resistant prostate cancer
Neal Shore, Jennifer Nguyen, Barinder Kang, Amrita Sawhney, Clare Byrne, Jackson Tang, Magdaliz Gorritz, Chi-Chang Chen, Jeetvan Patel · 2026
Read Real-world clinical outcomes and economic burden of discontinuation of taxane therapy among patients with metastatic castration-resistant prostate cancer by Neal Shore, Jennifer Nguyen, Barinder Kang, Amrita Sawhney, Clare Byrne, Jackson Tang, Magdaliz Gorritz, Chi-Chang Chen, Jeetvan Patel (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13401553.txt.
Description
Neal Shore and co-authors published a 2026 real-world study of what happens when men with metastatic castration-resistant prostate cancer stop second-line taxane chemotherapy early. Side effects often force discontinuation, and the team measured the survival and cost consequences using two large United States databases.
Survival came from the Flatiron Health records covering 2012 to 2020, while side effects and costs came from IQVIA claims for 2013 to 2021. Patients given a second androgen receptor drug instead lived a median of about 15 months versus about 14 months on taxane therapy. Among taxane patients, those completing more than eight cycles, 48 people, lived longer than the 166 who stopped at eight or fewer. The study pairs those outcome gaps with the adverse events and spending that early stopping involves.
Catalog record
| CREATOR | Neal Shore, Jennifer Nguyen, Barinder Kang, Amrita Sawhney, Clare Byrne, Jackson Tang, Magdaliz Gorritz, Chi-Chang Chen, Jeetvan Patel |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65942 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |