Bevacizumab plus iparomlimab/tuvonralimab with hepatic artery infusion chemotherapy followed by stereotactic body radiotherapy in patients with BCLC stage C hepatocellular carcinoma with thrombus and/or extrahepatic oligometastases (BITS-TO-HCC): study protocol of a prospective, single-center, single-arm, phase II study
Yuxin Liu, Haohua Wang, Kunli Zhu, Shumei Jiang, Fang Shi, Rui Feng, Xue Dou, Lei Xu, Zhe Gong, Shuai Wang, Chen Wang, Po Wang, Xiang Zhang, Jinbo Yue · 2026
Read Bevacizumab plus iparomlimab/tuvonralimab with hepatic artery infusion chemotherapy followed by stereotactic body radiotherapy in patients with BCLC stage C hepatocellular carcinoma with thrombus and/or extrahepatic oligometastases (BITS-TO-HCC): study protocol of a prospective, single-center, single-arm, phase II study by Yuxin Liu, Haohua Wang, Kunli Zhu, Shumei Jiang, Fang Shi, Rui Feng, Xue Dou, Lei Xu, Zhe Gong, Shuai Wang, Chen Wang, Po Wang, Xiang Zhang, Jinbo Yue (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13400948.txt.
Description
Yuxin Liu and a large team set out, in 2026, the protocol for a phase two trial in advanced liver cancer combining several treatments in sequence. Stage C disease with tumor growth into the portal vein or limited spread elsewhere is often inoperable and hard to treat, even with modern immunotherapy combinations.
Patients with preserved liver function will receive chemotherapy infused directly into the liver artery, followed in each cycle by two antibody drugs and a vessel-blocking antibody. After up to four cycles, those without progression get focused high-dose radiotherapy to remaining targets. Patients reaching complete response continue systemic therapy alone. The single-center, single-arm study will characterize safety, feasibility and efficacy of the sequence.
Catalog record
| CREATOR | Yuxin Liu, Haohua Wang, Kunli Zhu, Shumei Jiang, Fang Shi, Rui Feng, Xue Dou, Lei Xu, Zhe Gong, Shuai Wang, Chen Wang, Po Wang, Xiang Zhang, Jinbo Yue |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59130 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |