Cnicin Attenuates Aluminium Chloride–Induced Neurodegeneration Through Antioxidant and Anti-Inflammatory Mechanisms
Li Yu, Wardah A. Alhoqail, Suresh Mickymaray, Fang Li · 2026
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Description
Li Yu and colleagues test, in 2026, whether cnicin, a plant compound, protects rat brains against aluminum chloride poisoning used to mimic Alzheimer disease. The metal copies key features of the disease: oxidative stress, inflammation and disrupted memory chemistry. Few treatments modify Alzheimer progression, so natural candidates draw interest.
Rats got the metal alone, the metal with one of two cnicin doses, or the metal with the standard drug donepezil, over thirty days. Cnicin improved motor test scores, and higher doses helped more. It lowered a key enzyme tied to memory signaling. It also restored the rats own defenses and cut inflammation signs. Brain tissue kept its structure under the microscope, much like the standard drug group.
Catalog record
| CREATOR | Li Yu, Wardah A. Alhoqail, Suresh Mickymaray, Fang Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43070 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |