Focal hippocampal subfield atrophy in cognitively impaired relative to cognitively unimpaired older adults is associated with memory ability
Abi Heller‐Wight, David G Ellis, Anna Wilhelm, Caroline Nester Rooney, Nadia Pare, Nicole Sergeyev, Laura Rabin, David E Warren · 2026
Read Focal hippocampal subfield atrophy in cognitively impaired relative to cognitively unimpaired older adults is associated with memory ability by Abi Heller‐Wight, David G Ellis, Anna Wilhelm, Caroline Nester Rooney, Nadia Pare, Nicole Sergeyev, Laura Rabin, David E Warren (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13400838.txt.
Description
Abi Heller-Wight and colleagues examine, in 2026, whether shrinkage of specific parts of the hippocampus explains memory gaps in older adults. The hippocampus is a seahorse-shaped memory hub with distinct subfields. Whole-structure measures may hide where early pathological aging actually bites.
Participants ranged from cognitively healthy through subjective decline to mild cognitive impairment. All completed memory testing plus high-resolution brain scans. The mild impairment group had a smaller left hippocampus overall. Three left subfields were also smaller: the subiculum, CA1 and dentate gyrus. Modeling showed left subiculum and CA1 size predicted memory scores beyond the whole structure and other subfields. Focal measures, the authors argue, track memory more closely.
Catalog record
| CREATOR | Abi Heller‐Wight, David G Ellis, Anna Wilhelm, Caroline Nester Rooney, Nadia Pare, Nicole Sergeyev, Laura Rabin, David E Warren |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34857 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |