Alliin Regulates Intracellular Cholesterol Metabolism Through the PCSK9/LDLR Axis in Ox‐LDL‐Induced HepG2 Cells: A Proteomics Study
Yuanyuan Tang, Xiaoshi Liu · 2026
Read Alliin Regulates Intracellular Cholesterol Metabolism Through the PCSK9/LDLR Axis in Ox‐LDL‐Induced HepG2 Cells: A Proteomics Study by Yuanyuan Tang, Xiaoshi Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13400836.txt.
Description
Yuanyuan Tang and Xiaoshi Liu study, in 2026, how alliin, a garlic compound, changes cholesterol handling inside liver cells. Garlic compounds are candidate tools against the artery clogging that drives heart and brain disease. The team used a human liver cell line loaded with oxidized cholesterol to mimic a fatty, stressed state.
Alliin cut total cholesterol and triglyceride levels in the cells. Protein profiling found 67 changed proteins, concentrated in cholesterol metabolism and two signaling pathways. Crucially, alliin raised the receptor that pulls cholesterol from blood while lowering the protein that destroys that receptor, a pairing confirmed by targeted tests. The authors position alliin for further study in lipid disorders.
Catalog record
| CREATOR | Yuanyuan Tang, Xiaoshi Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31519 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |