LRBA regulates actin cytoskeleton dynamics through NMIIA during B cell immune responses
Elena Sindram, Juan Eduardo Montero-Hernández, Quentin Frenger, Hannah van Dijk, Anna Lang, Vanessa Zeidler, Rebecca Marsiske, Manuel Rhiel, Kerstin Geiger, Tatjana I Cornu, Emily M Mace, Volker Spindler, Joern Dengjel, Frédéric Gros, Bodo Grimbacher, Fernando E Sepulveda, Yolanda R Carrasco, Virginia Andreani, Laura Gámez-Díaz · 2026
Read LRBA regulates actin cytoskeleton dynamics through NMIIA during B cell immune responses by Elena Sindram, Juan Eduardo Montero-Hernández, Quentin Frenger, Hannah van Dijk, Anna Lang, Vanessa Zeidler, Rebecca Marsiske, Manuel Rhiel, Kerstin Geiger, Tatjana I Cornu, Emily M Mace, Volker Spindler, Joern Dengjel, Frédéric Gros, Bodo Grimbacher, Fernando E Sepulveda, Yolanda R Carrasco, Virginia Andreani, Laura Gámez-Díaz (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13400755.txt.
Description
Elena Sindram and many colleagues explain, in 2026, why B cells fail in people lacking a protein called LRBA. Patients with this deficiency suffer severe antibody problems, but the cellular cause was incomplete. B cells must rapidly reshape their internal skeleton to move, capture antigen and form an immune synapse.
The team found LRBA partners with a motor protein, non-muscle myosin IIA, that powers that reshaping. Without LRBA, B cells migrated abnormally, built less actin mesh, signaled weakly and failed to polarize toward antigen. Their immune synapses were disorganized and antigen uptake faltered. Motor activation marks also dropped. Together the findings position LRBA as a core organizer of B cell skeleton dynamics.
Catalog record
| CREATOR | Elena Sindram, Juan Eduardo Montero-Hernández, Quentin Frenger, Hannah van Dijk, Anna Lang, Vanessa Zeidler, Rebecca Marsiske, Manuel Rhiel, Kerstin Geiger, Tatjana I Cornu, Emily M Mace, Volker Spindler, Joern Dengjel, Frédéric Gros, Bodo Grimbacher, Fernando E Sepulveda, Yolanda R Carrasco, Virginia Andreani, Laura Gámez-Díaz |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 135715 |
| LICENSE | https://creativecommons.org/publicdomain/zero/1.0 |
| RIGHTS | CC0 |
| SOURCE | Europe PMC |