Substituent-rebound skeletal editing for precise boron-to-carbon single-atom swapping
Yan-Bo Li, Fu-Peng Wu, Jasper L. Tyler, Constantin G. Daniliuc, Frank Glorius · 2026
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Description
Yan-Bo Li and colleagues report, in 2026, a reaction that swaps a single boron atom for a carbon atom inside a ring molecule while keeping everything else in place. Such single-atom skeletal editing lets chemists isolate the effect of one atom change, a prized tool in drug design. Methods for it in aromatic systems are rare.
Their process converts ring compounds called benzazaborines into quinolines, using glyoxylic acid as the carbon source. The group originally attached to boron is caught and reattached to the product, making this a true single-atom swap rather than a rebuild. The reaction tolerated many functional groups and worked on late-stage derivatives of natural products and drugs. Detailed mechanism studies accompany the method.
Catalog record
| CREATOR | Yan-Bo Li, Fu-Peng Wu, Jasper L. Tyler, Constantin G. Daniliuc, Frank Glorius |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |