Gestational Protein Restriction Promotes Osteoporotic Phenotype During Aging
Bruno Calsa, Saul Lindo-Samanamud, Giovani Vinhato Breanza, Renata Marinho Melo, José Antônio Rocha Gontijo, Milton Santamaria-Jr, Patrícia Aline Boer · 2026
Read Gestational Protein Restriction Promotes Osteoporotic Phenotype During Aging by Bruno Calsa, Saul Lindo-Samanamud, Giovani Vinhato Breanza, Renata Marinho Melo, José Antônio Rocha Gontijo, Milton Santamaria-Jr, Patrícia Aline Boer (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13400681.txt.
Description
Bruno Calsa and co-authors show, in 2026, that feeding pregnant mice a low-protein diet leaves their offspring with weaker bones in old age. Poor nutrition before birth is known to shape later health, but effects on bone aging were not well mapped. Osteoporosis stems from failed bone renewal and crumbling internal structure.
Male offspring were examined at 12 and 18 months. Those from protein-restricted pregnancies had less spongy bone, lower mineral density and thinner outer bone by old age, and their thigh bones broke under less force. Microscopy showed more porous bone and disordered collagen fibers. Gene data pointed to a lasting shift in the bone immune environment, with more macrophage-linked signals and more bone-eating cell activity.
Catalog record
| CREATOR | Bruno Calsa, Saul Lindo-Samanamud, Giovani Vinhato Breanza, Renata Marinho Melo, José Antônio Rocha Gontijo, Milton Santamaria-Jr, Patrícia Aline Boer |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39433 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |