Context-Dependent Epithelial and Immune Programs Shape Intestinal Resilience or Vulnerability Following Prior Colitis
Priyanka Biswas, Vishwas Mishra, Julia Sanchez-Garrido, Gad Frankel · 2026
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Description
Priyanka Biswas, Vishwas Mishra, Julia Sanchez-Garrido and Gad Frankel ask, in 2026, whether a first bout of gut inflammation protects against, or worsens, a later one. Both infection-driven and chemical colitis damage the gut barrier and release inflammatory signals. The order of events, it turns out, matters.
Mice that recovered from a bacterial gut infection were shielded against later chemical colitis, with less weight loss and better preserved gut lining. That protection depended on the bacterium having injured the lining during the first illness and on sustained signaling by interleukin-17A. Mice recovered from chemical colitis fared oppositely: their barriers stayed leaky, immune cells lingered, and later infection hit them harder, even from weakened bacteria.
Catalog record
| CREATOR | Priyanka Biswas, Vishwas Mishra, Julia Sanchez-Garrido, Gad Frankel |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 75923 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |