CXCL8 producing macrophages shape gastric cancer outcomes
Lin Zhang, Hanming Yu, Han Zhang, Yang Zhou, Zhanjun Miao, Yuanzeng Zhu · 2026
Read CXCL8 producing macrophages shape gastric cancer outcomes by Lin Zhang, Hanming Yu, Han Zhang, Yang Zhou, Zhanjun Miao, Yuanzeng Zhu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13400654.txt.
Description
Lin Zhang and co-authors build, in 2026, a chemokine-based score for predicting outcomes in stomach cancer, then trace its key signal to macrophages. Chemokines are messenger proteins that shape the tumor surroundings, but their combined prognostic value was unclear. Stomach cancer still kills many patients worldwide.
Merging gene data from public cancer cohorts, the team built a six-chemokine signature that split patients into high and low risk groups with clearly different survival. The score predicted outcome independently of other factors. Single-cell analysis then showed macrophages, a type of immune cell, were the main source of the top chemokine, CXCL8. Those high-producing macrophages looked tumor-friendly and sat at the center of local signaling, making the axis a possible drug target.
Catalog record
| CREATOR | Lin Zhang, Hanming Yu, Han Zhang, Yang Zhou, Zhanjun Miao, Yuanzeng Zhu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48437 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |